For a drug that flopped in clinical trials, Viagra has subsequently been an extraordinary success story. When scientists first concocted the little blue pill more than 20 years ago, it was as a treatment for the heart condition angina.

The idea was that it would ease pain by dilating blood vessels around the heart.

The results were disappointing, until doctors noticed an extraordinary side-effect among male volunteers.

"Researchers knew they were on to something when patients refused to give the drugs back at the end of the trial," says Dr Mike Kirby, adviser to the Sexual Dysfunction Association.

Viagra generates sales of more than £1 billion a year and, as well as providing effective treatment for erectile dysfunction, is attracting interest as a potential remedy for a range of other illnesses from deadly lung disorders to cold hands.

The secret of Viagra, and other drugs in the same class, is that they allow blood to flow more freely by helping arteries to relax. They do this by blocking the effects of an enzyme called phosphodiesterase.

Evidence suggests it could even be used to combat jet lag.

Below, we examine other ways the modern day wonder-drug could help repair the damaged body. In most cases, research is still at an early stage and the drug is not yet being widely used. In others, such as the deadly lung disease pulmonary arterial hypertension, a form of the drug is already being used to save lives in Britain.

HEART ATTACKS

Giving Viagra after a heart attack could repair damaged muscle by restoring oxygen supplies. Researchers at Virginia Commonwealth University in the U.S. compared the antiimpotence drug with nitroglycerin, the standard treatment given to heart attack victims, and found Viagra was better at restoring bloodflow and helping tissue heal.

BREAST CANCER

Breast and colon tumours in mice shrank threefold when they were injected with the drug in experiments at Johns Hopkins University in the U.S. Scientists believe Viagra works by 'unmasking' cancer cells, so the immune system can recognise them as foreign and destroy them.

COLD HANDS

Raynaud's disease affects up to one in five people and is caused when blood supply to fingers and toes is interrupted. Most of the time they appear cold, white and look dead, but exposure to cold can trigger a burning sensation. Patients given 50mg of Viagra twice a day, for four weeks, had fewer and much shorter 'burning' attacks due to better bloodflow.

CROHN'S DISEASE

British researchers claim the sex pill could fight Crohn's disease, a debilitating condition, which often needs major surgery on the bowel. Tests at University College London showed the drug boosts bloodflow around the small intestine - the area most affected by the disease - and helps fight bacteria..

INFERTILITY

A woman's chances of becoming pregnant could improve, according to scientists. In some women, the lining of the uterus is too thin to sustain a pregnancy. The drug increases bloodflow to the uterus and stimulates growth of cells.

DIABETES

Three out of four diabetics suffer gastroparesis - when the stomach empties too slowly. It causes loss of appetite and dehydration. U.S. scientists found Viagra helped by relaxing stomach muscles.

PELVIC PAIN

Up to 50 per cent of men suffer pelvic pain, causing discomfort around the lower back and groin.

Viagra appears to help by dilating blood vessels in the pelvic area and boosting bloodflow, according to a trial at Washington University in the U.S..

STILL BIRTHS

Every year, about 600 babies in the UK are stillborn because of a pregnancy disorder called pre-eclampsia. But foetal deaths dropped sharply in pregnant mice given the Viagra. In pre-eclampsia, arteries feeding the placenta do not widen enough to deliver all the blood the baby needs. Viagra relaxes muscles in the artery walls.

LUNG DISEASE

Nobody knows what causes pulmonary arterial hypertension, a condition that affects about 4,000 people in the UK, often women in their 30s and 40s. But few sufferers survive beyond three to four years. Blood pressure becomes dangerously high in the pulmonary artery. A Viagra-based drug called Revatio is extending the lives of some sufferers by boosting blood flow to the lungs, reducing the workload on the heart.

PROSTATE PROBLEMS

The little blue pill can improve symptoms of benign prostatic hyperplasia. BPH is part of the natural ageing process and nothing to do with prostate cancer. But it does cause frequent urinating, bladder stones, depression and daytime tiredness due to constant broken sleep. Doctors at Northwestern University in Chicago tested the drug on 300 men - it had a dramatic effect..

Source: -http://www.dailymail.co.uk

Acomplia, as all of us knows a drug which helps to loose weight. But are you sure that it can work for everyone. Diet pills are principally designed for those suffering from serious obesity - e.g. with a body mass index of 35+.It not means that you will take medicine and definitely start to loose weight.
Diet and weight loss drugs are not a cosmetic solution for weight loss, neither are they intended to replace convention diet and weight loss programs. Dieters who fail to lose weight on orthodox diet plans should not turn to pills as an easy answer to their weight problems. Instead they should continue with their weight loss diet and work on improving their motivation to lose weight and exercise.

Acomplia was launched in the year 2006, and since then there is no looking back. Acomplia with Rimonabant as its active ingredient is a product of 2 years of clinical trails.

Over-active appetite receptors indicate that the urge to eat is more, and thereby the greater tendency to gain weight. Use of Acomplia basically puts a check on this, and in this way aids in suppressing appetite.

Use of this medication is suggested to be combined with a balanced diet and regular workout regime to fetch effective results. It is suggested to be taken on an empty stomach with a glass of water.

* Eat Breakfast Every day

* Eat a Moderately Low-Fat, High-Carbohydrate Diet

* Keep Track of your Progress and Meals with Journals and Food Planners

* Use Weigh-in's to Keep Honest and Motivated

* Exercise 60-90 Minutes per Day

Obesity and over weight is a highly talked about modern disease and hence a lot of studies and researches have been done in order to find out the reasons and medicine of obesity. Obesity is dependant on the daily calorie intake of an individual and hence its total thanks goes to the food we consume on a daily basis.

Obesity and overweight are the members of the same family of disease i.e. weight gain. And obesity and overweight also welcomes the most dangerous problems like heart stroke, diabetes and cholesterol problems etc. women’s fertility is also being negatively affected by obesity. Obesity in general terms is termed as the excess of fats accumulation on one’s body and in the medical it is define as a BMI (body mass index) of 30 or more than it.

So the first choice of a person while deficient to have a weight loss is control over the calorie intake, for that anti obesity pills such as Acomplia are an effective medication. Being an appetite suppressant helps the patients to have a control over the calorie intake by controlling their dietary habits. Acomplia is a multipurpose pill as well as It also help in quit the unhealthy habit of smoking. Moreover it helps people get better cardiovascular conditions with a healthier life. Acomplia diet pill works by controlling the central nerves that helps reducing the urge to eat frequently.

* Individual or community orientations - some communities revere obesity and regard fat individuals as healthy, free of Aids and beautiful, as is often the case in African societies. Trying to persuade a member of such a community that weight loss is essential, is a losing battle.

* Speed of gratification - modern people are addicted to 'instant fixes'. Whereas our ancestors were patient and prepared to work and wait for result or changes, modern man expects solutions in a wink and many people are not prepared to take time and care to lose weight. I have endless comments from Readers who bewail the fact that they have been on a diet for a week 'and not lost a kg!'. Weight loss takes time and effort, two concepts that are at odds with the modern need for instant gratification.

* Perceived benefits - this value can make any weight loss programme fail, because it is practically impossible to motivate someone to lose weight if they cannot perceive the benefit of doing so. If you are not deeply convinced that losing weight will improve your health and lifestyle, then don't even start a diet, it will be doomed to failure.

* Locus of control - the question of who controls your life is also important. Do you feel that you are in control of your life and all its aspects, or do you feel like a helpless baby torn in different directions by forces beyond your control? If you belong to the latter group, you will also fail when trying to lose weight, because it take control to stick to a diet and an exercise programme.

* Aspirations - these values define your goals. If you are determined to reach your gaol of weight loss then chances are you will get there with flying colours, but if you don't even have any aspirations and just vaguely think you should be doing something about being obese because someone else thinks so, your chances are poor.

Generally, what we understand when we first hear about Cialis is the fact that this is the first true competitor of Viagra as it fights against erectile dysfunction as well as the first mentioned. Viagra appeared in 1998 and registered a high success generally for the fact that it was the first product of this kind. Nowadays a new successful product was attributed to ICOS Corporation which is to shatter the unbelievable success of Viagra. The series isn't ending here; anyway, as another one called Levitra.

First of all, there should be mentioned that the sell market of Cialis has reached an enormous level which is bound to put aside the success registered by Viagra in the late 90's. What is important is the fact that from around thirty million people suffering from erectile dysfunction in the USA and another estimated number of one hundred and seventy five million abroad who are having this dysfunction and using these products, only a little part are using Viagra.

Like Viagra, an estimated number of eighty percent of the people who have tried Cialis have had the opportunity and chance in the mean time to have an erection as well as sexual acts but in comparison with Viagra, the effects and potential of the user lasted for more than thirty six hours after taking the pill; in this period of time the effects were almost constant. A possible explanation for this is the fact that Cialis persists longer in the body than Viagra does. The period of time for blood levels to fall fifty percent for Viagra records four hours, while Cialis makes it up to seventeen hours. This can signify that a twenty five percent of the original doze of Cialis is still in the body at that time.

To conclude, it may be said that Cialis has finally shattered the’ unbreakable’ myth of Viagra by adding more tough points to the well-known advantages of Viagra. Logically, it is of a higher quality technique than Viagra this being the reason for the extreme surpassing. Let’s hope things will not remain this way and will improve more and more up to perfection.

Food cravings and drug addiction affected the brain similarly in studies, suggesting new weight-loss medicines may help treat recovering addicts.

Brain scans of 18 cocaine addicts found that when they thought about drugs they exhibited higher levels of dopamine, a chemical tied to feelings of reward and pleasure, in a brain region that's also activated by food deprivation. Other studies showed reduced sensitivity in the reward circuits of both addicts and obese people, possibly leading them to compensate with drugs or overeating.

The data is to presented Friday at a meeting in San Francisco. Pfizer Inc., Sanofi-Aventis SA and Bristol-Myers Squibb Co. are developing new types of diet pills that work by blocking hunger signals in the brain. Some U.S. health officials hope to capitalize on the drugmakers' research by testing the compounds on smoking, alcoholism and other substance abuse.

While drugmakers are racing to gain a piece of the market for treating the two-thirds of Americans who are overweight, companies so far have been reluctant to invest in new addiction treatments. Acomplia, which was introduced in Europe in July, suffered its third delay in U.S. approval this week. Until medicines are cleared for sale by the Food and Drug Administration, scientists need the backing of companies to gain access to test their compounds.

One of Monroe County's largest employers could become the world's largest drug company if an expected deal takes place.

Sanofi-Aventis and Bristol-Myers Squibb are planning a friendly merger, according to multiple reports.

Sanofi, based in France, has more than 1,500 employees in the Poconos. If Sanofi buys U.S.-based Bristol-Myers, it would top Pfizer as the biggest pharmaceutical company in the world.

The merger would increase Sanofi's U.S. sales force in advance of its launch of a new anti-obesity drug called Acomplia, according to Business Week.

Industry experts say the biggest merger benefit for Sanofi would be tapping the Bristol-Myers pipeline of new products as both companies face a decrease in sales when many of their best sellers lose their patent protection in a few years.

Sanofi-Aventis was created in 2004 when Aventis accepted a bid for $65.4 billion from French drug-maker Sanofi-Synthelabo. The deal created the world's third-largest pharmaceutical company.

Sanofi, the largest maker of flu vaccine, is routinely praised by Monroe County leaders for providing high-paying, high-tech jobs.

Sanofi's products include allergy medicine Allegra and sleep aid Ambien. Bristol-Myers' products include the blood-thinner Plavix. Sanofi-Aventis conducts business in the U.S. through its headquarters in Bridgewater, N.J. The company has 16,000 employees in the U.S.

Source: poconorecord.com

The media, movies, literature have just one word in common…sex. The liberated world of today discusses sex in forums, on the coffee table, in offices and all places one can think of, except the bedroom. Sex is increasingly become the in vogue topic of the generation X.

With so much of information explosion about this once taboo topic, one would think that the today’s world knows all there is to know about sex. It would be natural to believe that this liberation has led to happy relationships and increased marital satisfaction amidst couples. However, nothing can be further away from the truth. Today, the divorce rates are increasing at an alarming rate. Breakups between couples have become as common as having tea or coffee. Marriages are increasingly becoming a standing joke in the society. Infidelity is taken as casually as changing clothes.

What are the reasons behind the dwindling “till death does us apart relationships”? The reasons are simple. They can be termed as lack of commitment, patience and understanding. Today’s world survives on fast food and quick fixes and so is the case with relationships.

Today people do not invest time in a relationship. The contemporary couple does not have time to understand each others problems and issues. Instead all they want is a quick intercourse and sleep. To increase their sexual satisfaction, they do not look for partner’s satisfaction; instead they use quick fixes like cialis which helps to satisfy them. Though these pills come in cheap but they come with side effects.

Sexual satisfaction cannot be obtained from pills like cialis which are easily available online. This satisfaction can only be achieved by loving your partner’s mind body and soul. As Freud once said – sex is in the mind.